# US 12,109,136 B2 · Devices and methods to treat and prevent diverticulitis > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,109,136 B2 - Document ID: US12109136B2 - Status: Granted - Kind: B2 - Application number: 17/185,592 - Filed: 2021-02-25 - Published: 2021-08-26 - Granted: 2024-10-08 - Earliest claimed: 2020-02-25 - Assignees: Gyrus ACMI, Inc. - Applicants: Gyrus Acmi, Inc. - Inventors: Nikhil M. Murdeshwar; Thomas J. Holman - Web page: https://patentgrep.com/patent/US12109136B2 ## CPC - A61F 2/962: having an outer sleeve - A61B 17/00234: {for minimally invasive surgery (A61B17/0218, A61B17/0469, A61B17/12013, A61B17/1285, A61B17/29, A61B17/320016 take precedence)} - A61B 17/00491: {Surgical glue applicators} - A61B 17/12: for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord - A61B 17/12013: {for use in minimally invasive surgery, e.g. endoscopic surgery} - A61B 18/1477: {Needle-like probes} - A61F 2/82: Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents (stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07) - A61F 2/95: Instruments specially adapted for placement or removal of stents or stent-grafts - A61F 7/12: Devices for heating or cooling internal body cavities - A61K 9/0009: {involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis} - A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)} - A61K 9/1676: {having a drug-free core with discrete complete coating layer containing drug (adsorbates of liquid drug formulations on inert powders without simultaneous granulation step A61K9/141; with further drug-free outer coating A61K9/5078; drug conjugated to non-active particles A61K47/6921)} - A61K 33/38: Silver; Compounds thereof - A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca - A61M 31/00: Devices for introducing or retaining media, e.g. remedies, in cavities of the body (A61M25/00 takes precedence {; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008}) - A61B 1/018: for receiving instruments - A61B 1/31: for the rectum, e.g. proctoscopes or sigmoidoscopes - A61B 2017/00278: {Transorgan operations, e.g. transgastric} - A61B 2017/0034: {adapted to be inserted through a working channel of an endoscope} - A61B 2017/00349: {Needle-like instruments having hook or barb-like gripping means, e.g. for grasping suture or tissue (A61B17/06066 takes precedence)} - A61B 2017/00473: {Distal part, e.g. tip or head (A61B2017/00464 takes precedence)} - A61B 2017/00557: {inflatable (A61B2017/22051 takes precedence)} - A61B 2017/00818: {Treatment of the gastro-intestinal system} - A61B 2017/12018: {Elastic band ligators} - A61B 2018/00005: {Cooling or heating of the probe or tissue immediately surrounding the probe} - A61B 2018/00279: {deployable} - A61B 2018/00291: {using suction} - A61B 2018/00494: {Stomach, intestines or bowel} - A61B 2090/037: {with a frangible part, e.g. by reduced diameter} - A61B 2217/005: with suction drainage system - A61B 2217/007: with irrigation system - A61B 2218/007: Aspiration - A61F 2210/0014: using shape memory or superelastic materials, e.g. nitinol - A61F 2210/0076: multilayered, e.g. laminated structures - A61F 2220/005: using adhesives - A61M 2202/0007: introduced into the body - A61M 2202/06: Solids - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A method of treating diverticulitis while maintaining the bioactivity of the diverticulum. The devices and methods include placing an endoscopic device within a colonic lumen relative to at least one diverticulum and inserting a plurality of particles into the at least one diverticulum. The plurality of particles can include magnetic particles, non-magnetic particles, or both. The plurality of particles can partially or totally occlude the diverticulum preventing unwanted material from entering the diverticulum. Additionally, the plurality of particles can include antimicrobial and therapeutic layers that can treat diverticulitis and prevent or minimize diverticulitis from occurring. ## Claims ### Claim 1 A method of treating diverticulitis, the method comprising: placing an endoscopic device within a colonic lumen relative to a diverticulum; advancing a delivery shaft from the endoscopic device and into the diverticulum; and releasing a plurality of particles into the diverticulum, wherein the plurality of particles includes a plurality of magnetized particles, a plurality of non-magnetized particles and one or more therapeutic agents to treat the diverticulitis and form a cluster formation to at least partially occlude the diverticulum. ### Claim 2 (depends on 1) The method of claim 1, wherein at least a portion of the plurality of the magnetized particles include a magnetic core and at least one of an antimicrobial coating and a therapeutic coating. ### Claim 3 (depends on 2) The method of claim 2, wherein the antimicrobial coating is positioned between the magnetic core and the therapeutic coating. ### Claim 4 (depends on 3) The method of claim 3, wherein the therapeutic coating is biodegradable. ### Claim 5 (depends on 3) The method of claim 3, wherein the antimicrobial coating includes silver. ### Claim 6 (depends on 1) The method of claim 1, wherein the plurality of non-magnetized particles include bio-degradable medicated particles. ### Claim 7 (depends on 1) The method of claim 1, wherein, prior to releasing the plurality of particles, the method further includes: positioning a stent in within the diverticulum, the stent including a bioadhesive; expanding the stent to contact and adhere to an inner surface of the diverticulum; and after releasing the plurality of particles, collapsing the stent around the plurality of particles. ### Claim 8 (depends on 1) The method of claim 1, wherein, prior to releasing the plurality of particles, the method further includes at least one of: aspirating the diverticulum utilizing an aspiration device in operable cooperation with the endoscopic device, the aspiration device configured to suction undesirable material from the at least one diverticulum; and irrigating the at least one diverticulum utilizing an irrigation device in operable cooperation with the endoscopic device, a lavage device configured to extend distally from the endoscopic device and to utilize fluid to flush out the at least one diverticulum. ### Claim 9 (depends on 1) The method of treating diverticulitis of claim 1, including: forming the plurality of particles into an agglomeration, at least a portion of the plurality of particles includes the one or more therapeutic agents; retaining the agglomeration within the diverticulum; and while retaining the agglomeration within the diverticulum releasing the one or more therapeutic agents. ### Claim 10 A system for treating diverticulitis, comprising: a plurality of particles configured to be injected into a diverticulum, wherein the plurality of particles includes: a plurality of magnetized particles having a magnetic core and at least an antimicrobial coating. ### Claim 11 (depends on 10) The system of claim 10, wherein at least a portion of the plurality of magnetized particles further include a biodegradable therapeutic coating. ### Claim 12 (depends on 10) The system of claim 10, wherein the plurality of particles further includes a plurality of biodegradable particles including a therapeutic agent. ### Claim 13 (depends on 12) The system of claim 12, wherein the therapeutic agent is selected from at least one of an antibiotic agent, beneficial flora, an antimicrobial agent, growth factors, growth inhibitors, an antiseptic agent, an anti-inflammatory agent, an antirestinosis agent, or an antioxidant. ### Claim 14 (depends on 10) The system of claim 10, wherein the antimicrobial coating includes silver. ### Claim 15 (depends on 10) The system of claim 10, wherein the plurality of magnetized particles include: a main particle having a first maximum dimension, the main particle being selectively magnetized to include a plurality of magnetic attachment locations; and a plurality of attachment particles having a second maximum dimension that is less than the first maximum dimension, wherein the plurality of attachment particles adhere together to form arms that adhere to the main particle at the plurality of magnetic attachment locations. ### Claim 16 (depends on 10) The system of claim 10, wherein the plurality of magnetized particles include: a main particle having an outer surface having a plurality of openings extending from the outer surface to a cavity; a magnetic particle positioned within the cavity of the main particle; and a plurality of attachment particles having a size less than a size of the plurality of openings, wherein the magnetic particle is configured to attract the plurality of attachment particles such that the plurality of attachment particles are configured to move through the openings and attach to the magnetic particle. ### Claim 17 (depends on 10) The system of claim 10, further including: an endoscopic device including a deliver shaft having a flexible tip that is configured to release a single particle of the plurality of particles at a time. ### Claim 18 A method of treating diverticulitis, the method comprising: advancing a delivery shaft from an endoscopic device positioned within a colonic lumen and into a diverticulum; and releasing a plurality of magnetic particles into the diverticulum, wherein the plurality of magnetic particles have a predetermined cluster formation, the predetermined cluster formation having at least one dimension that is greater than a dimension of an ostia of the diverticulum. ### Claim 19 (depends on 18) The method of claim 18, wherein at least a portion of the plurality of the magnetized particles include a magnetic core and at least one of an antimicrobial coating and a therapeutic coating. ### Claim 20 (depends on 18) The method of claim 18, including: releasing a plurality of non-magnetic biodegradable medicated particles into the diverticulum.