Bone replacement implants with mechanically biocompatible cellular material

A bone implant adapted to be received within a host bone, the bone implant comprising:

• a lattice microstructure having a plurality of interconnected unit cells, the lattice microstructure having a non-homogeneous distribution of material therewithin, and each of said unit cells having a cell topology, and a pore geometry defined by pore size, pore shape and wall thickness;
• wherein said non-homogeneous distribution of material includes a non-homogeneous distribution of said cell topology within the lattice microstructure and a non-homogeneous distribution of said pore geometry within the lattice microstructure, a portion of the lattice microstructure having properties graded based on loading conditions at a bone-implant interface defined between the portion of the lattice microstructure and a portion of the host bone;
• and
• wherein the properties that are graded include the pore size of the unit cells, a porosity of the lattice microstructure and the wall thickness of the unit cells, the pore size of the unit cells at the bone-implant interface being in the range between 50 micron and 800 micron, the porosity of the lattice microstructure being greater than 40%, and the wall thickness of the unit cells being in the range from 70 micron to 100 micron, and wherein the lattice microstructure has a predetermined density pattern in the bone implant that is configured to minimize bone loss and interface failure.