# US 12,109,102 B2 · Aortic protection

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- Number: US 12,109,102 B2
- Document ID: US12109102B2
- Status: Granted
- Kind: B2
- Application number: 16/650,918
- Filed: 2018-09-27
- Published: 2020-08-27
- Granted: 2024-10-08
- Earliest claimed: 2017-09-28
- Applicants: Zeev Brandeis
- Inventors: Zeev Brandeis
- Web page: https://patentgrep.com/patent/US12109102B2

## CPC

- A61F 2/01: Filters implantable into blood vessels
- A61F 2/0105: {Open ended, i.e. legs gathered only at one side}
- A61F 2/011: {Instruments for their placement or removal}
- A61B 2017/00778: {Operations on blood vessels (A61B2017/22097, A61B2017/320741 take precedence)}
- A61B 2017/22079: {with suction of debris}
- A61F 2/24: Heart valves {; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body}
- A61F 2002/0081: {directly machined on the prosthetic surface, e.g. holes, grooves (A61F2/30771 takes precedence)}
- A61F 2002/016: {made from wire-like elements}
- A61F 2002/068: {Modifying the blood flow model, e.g. by diffuser or deflector}
- A61F 2210/0014: using shape memory or superelastic materials, e.g. nitinol
- A61F 2210/0076: multilayered, e.g. laminated structures
- A61F 2230/0013: Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
- A61F 2230/0069: cylindrical
- A61F 2250/0004: adjustable
- A61F 2250/0023: differing in porosity
- A61F 2250/0063: Nested prosthetic parts
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

An aortic protection device including a mesh lumen shaped and sized to extend along the aorta, from a heart-side of a brachiocephalic artery exit from the aorta to distal of a left subclavian artery exit from the aorta, wherein the mesh lumen is arranged to change a porosity of mesh pores in response to external control. Related apparatus and methods are also described.

## Claims

### Claim 1

An aortic protection device comprising:
a heart-proximal ring; and
a mesh lumen portion connected to the heart proximal ring, shaped and sized to extend along the aorta, from a heart-side of a brachiocephalic artery exit from the aorta to distal of a left subclavian artery exit from the aorta, and
a mechanism for changing a porosity of mesh pores in response to external control of a control wire attached to a heart-proximal end of the mesh lumen portion and a control wire attached to a more heart-distal part of the mesh lumen portion, while said mesh lumen remains anchored to the aorta in a manner which allows filtering of blood- borne debris from passing through said arteries;
wherein the mesh lumen portion is arranged to change a porosity of the mesh pores to completely block blood from entering side arteries.

### Claim 2 (depends on 1)

The device of claim 1, wherein the mesh lumen portion is arranged to change the porosity of the mesh pores in response to manipulating a proximal end of the mesh lumen portion relative to a distal end of the mesh lumen portion.

### Claim 3 (depends on 1)

The device of claim 1, wherein the mesh lumen portion is arranged to change the porosity of the mesh pores in response to twisting a proximal end of the mesh lumen portion relative to a distal end of the mesh lumen portion.

### Claim 4 (depends on 1)

The device of claim 1, wherein the mesh lumen portion is arranged to be reshaped as a narrower lumen in response to external control.

### Claim 5 (depends on 1)

The device of claim 1, in which the mesh lumen portion is arranged to change a porosity from pores sized in a range between 200 microns to 100 microns to pores sized in a range between 100 to 10 microns.

### Claim 6 (depends on 1)

The device of claim 1, in which the mesh lumen portion comprises a first mesh lumen comprising shape-memory material and a second mesh lumen comprising flexible material co-axial with the first mesh lumen.

### Claim 7 (depends on 6)

The device of claim 6, in which the first mesh lumen is not attached to the second mesh lumen along most of a length of the first mesh lumen.

### Claim 8 (depends on 6)

The device of claim 6, in which a flexible material outside mesh lumen has a greater diameter than a shape memory inside mesh lumen, enabling the outside mesh lumen to extend into arteries branching off the aorta.

### Claim 9 (depends on 6)

The device of claim 6, in which a flexible material inside mesh lumen is shaped to contract away from a shape memory outside mesh lumen, reducing pore size of the flexible material inside mesh lumen.

### Claim 10 (depends on 6)

The device of claim 6, in which the first mesh lumen is arranged to form an elongated shape with a horseshoe shaped cross section relative to a longitudinal direction of the lumen.

### Claim 11 (depends on 1)

The device of claim 1, in which the mesh lumen portion comprises two flexible mesh lumens, one within another and co-axial.

### Claim 12 (depends on 1)

The device of claim 1, in which the mesh lumen portion comprises:
a first mesh lumen comprising shape-memory material;
a second mesh lumen comprising flexible material; and
a third mesh lumen comprising flexible material,
wherein the second mesh lumen and the third mesh lumen are co-axial with the first mesh lumen.

### Claim 13 (depends on 1)

The device of claim 1, in which the mesh lumen is produced by weaving polymer threads.

### Claim 14 (depends on 1)

The device of claim 1 arranged to change porosity after the anchoring and the deploying.

### Claim 15 (depends on 1)

The device of claim 1 comprising a wire arranged for removing the device from a patient body, the wire sized to extend from the aorta to external to a patient's body.

### Claim 16 (depends on 1)

The aortic protection device of claim 1, wherein the heart-proximal ring is configured to remain expanded against the walls of the aorta even when the mesh lumen is made narrow.

### Claim 17

A method of protecting a patient from blood-borne debris, comprising:
anchoring an aortic protection device comprising anchoring a heart-proximal ring connected to a mesh lumen portion at a heart-side of a brachiocephalic artery exit from an aorta;
deploying the mesh lumen to extend to distal of a left subclavian artery exit from the aorta, and
controlling the mesh lumen to decrease porosity of the mesh pores during a heart operation, while the aortic protection device remains anchored and deployed such that the mesh lumen filters blood flow to arteries branching off the aorta and blocks at least some blood-borne debris from entering thereto, thereby protecting the patient from blood-borne debris;
wherein the controlling comprises completely blocking blood from entering side arteries.

### Claim 18 (depends on 17)

The method of claim 17, wherein the controlling comprises manipulating a proximal end of the mesh lumen portion relative to a distal end of the mesh lumen portion.

### Claim 19 (depends on 17)

The method of claim 17, wherein the controlling comprises reshaping the mesh lumen portion as a narrower lumen than when anchoring the heart-proximal ring, retracting toward a center of the aorta.

### Claim 20 (depends on 17)

The method of claim 17, in which the controlling the mesh lumen to change porosity of the mesh pores comprises changing porosity from pores sized in a range between 200 microns to 100 microns to pores sized to a range less than 100 microns.

### Claim 21 (depends on 17)

The method of claim 17, wherein the controlling comprises decreasing pore size just before performing a medical procedure on a heart which may dislodge debris.

### Claim 22 (depends on 17)

The method of claim 17, wherein the controlling comprises increasing pore size after performing a medical procedure on a heart which may dislodge debris.

### Claim 23 (depends on 17)

The method of claim 17, comprising maintaining the decreased porosity over a time which overlaps with manipulation of a cardiac structure.

### Claim 24 (depends on 23)

The method of claim 23, wherein said manipulation comprises an implantation or repair of a cardiac valve.

### Claim 25 (depends on 23)

The method of claim 23, wherein said deploying comprises deploying after a medical procedure on the heart has started and comprising maintaining the decreased porosity during at least part of a surgical operation on a heart or heart valve.