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US 12,109,023 B2Granted
Thermally stable glucose limiting membrane for glucose sensors
AssigneeMedtronic MiniMed, Inc.
InventorsJenn-Hann Larry Wang, Dero Hovanes, Poonam S. Gulati
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Abstract
Embodiments of the invention provide compositions useful in analyte sensors as well as methods for making and using such compositions and sensors. In typical embodiments of the invention, the sensor is a glucose sensor comprising an analyte modulating membrane formed from a polymeric reaction mixture formed to include limiting amounts of catalyst and/or polycarbonate compounds so as to provide such membranes with improved material properties such as enhanced thermal and hydrolytic stability.
Claims8
A method of making an analyte sensor for implantation within a mammal comprising the steps of:
- providing a base layer;
- forming a conductive layer on the base layer, wherein the conductive layer includes a working electrode;
- forming an analyte sensing layer on the conductive layer, wherein the analyte sensing layer includes an oxidoreductase;
- forming an analyte modulating layer on the analyte sensing layer, wherein the analyte modulating layer:
- (a) is formed by a reaction mixture comprising:
- from 17% to 23% weight percent hexamethylene diisocyanate;
- from 0% to 8.5% weight percent methylene diphenyl diisocyanate;
- from 14% to 48% weight percent polydimethylsiloxane having amino terminal groups;
- and from 7.5% to 19% weight percent poly(1,6-hexyl carbonate) diol;
- and
- a catalyst present in the reaction mixture in amounts less than 0.2% of reaction mixture components;
- and
- (b) exhibits a greater thermal stability than a comparable analyte modulating layer formed from a reaction mixture where the catalyst is present in the formulation in amounts greater than or equal to 0.2% of the reaction mixture.
10 more elements
Dependencies are inferred from the claim text.