# US 12,109,014 B2 · System and method for metabolic measurements > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,109,014 B2 - Document ID: US12109014B2 - Status: Granted - Kind: B2 - Application number: 17/023,483 - Filed: 2020-09-17 - Published: 2021-06-17 - Granted: 2024-10-08 - Earliest claimed: 2019-12-12 - Assignees: Koninklijke Philips N.V. - Applicants: Koninklijke Philips N.V. - Inventors: Roberto Buizza; Francesco Vicario - Web page: https://patentgrep.com/patent/US12109014B2 ## CPC - A61B 5/0836: {Measuring rate of CO2 production} - A61B 5/0833: {Measuring rate of oxygen consumption} - A61B 5/72: {Signal processing specially adapted for physiological signals or for diagnostic purposes} - A61B 2562/02: Details of sensors specially adapted for in-vivo measurements - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract The present disclosure pertains to a system for metabolic measurements, the system comprising: a metabolic monitor configured to determine first concentration measurements of O2 and CO2 in a portion of gas exhaled by a subject during one or more breaths; and determine a first rate of O2 consumption (VO2) and a first CO2 volume production (VCO2) of the subject during the one or more breaths based on the determined first O2 concentration and the determined first CO2 concentration; a CO2 monitor configured to determine second CO2 concentration measurements in the exhaled gas during the one or more breaths; and determine second CO2 volume production (VCO2) of the subject based on the measured second CO2 concentration; and processors configured to determine a correction factor based on the determined first VCO2 and the second VCO2; and determine a corrected first VO2 using the correction factor and the first VO2. ## Claims ### Claim 1 A system for metabolic measurements, the system comprising: a metabolic monitor configured to: determine first concentration measurements of O2 and CO2 in a portion of gas exhaled by a subject during one or more breaths; and determine a first rate of O2 consumption (VO2) and a first CO2 volume production (VCO2) of the subject during the one or more breaths based on the determined first O2 concentration in the portion of the exhaled gas and the determined first CO2 concentration in the portion of the exhaled gas; a CO2 monitor configured to: determine second CO2 concentration measurements in the gas exhaled by the subject during the one or more breaths; and determine second CO2 volume production (VCO2) of the subject during the one or more breaths based on the measured second CO2 concentration; and one or more physical computer processors operatively connected the metabolic monitor and the CO2 monitor, the one or more physical computer processors configured by computer readable instructions to: determine a correction factor based on the determined first VCO2 and the second VCO2; and determine a corrected first VO2 using the correction factor and the first VO2. ### Claim 2 (depends on 1) The system of claim 1, wherein the correction factor is determined as a quotient of the second VCO2 from the CO2 monitor and the first VCO2 from the metabolic monitor. ### Claim 3 (depends on 1) The system of claim 1, wherein the corrected first VO2 is a product of the correction factor and the first VO2. ### Claim 4 (depends on 1) The system of claim 1, wherein the CO2 monitor is a capnograph. ### Claim 5 (depends on 1) The system of claim 1, wherein the one or more physical computer processors are configured to determine a corrected first VCO2 using the correction factor and the determined first VCO2. ### Claim 6 (depends on 5) The system of claim 5, wherein the one or more physical computer processors are configured to determine a metabolic status of the subject based on the corrected first VO2 and the corrected first VCO2. ### Claim 7 (depends on 5) The system of claim 5, wherein the one or more physical computer processors are configured to measure energy expenditure (EE) and/or respiratory quotient (RQ) based on the corrected first VO2 and corrected first VCO2. ### Claim 8 (depends on 1) The system of claim 1, wherein: the metabolic monitor comprises a plurality of sensors configured to output signals related to one or more breathing parameters of the subject during one or more breaths; and the one or more physical processors are further configured to determine the first concentration measurements of O2 and CO2 of the portion of the exhaled gas by the subject based on the one or more breathing parameters of the subject. ### Claim 9 (depends on 8) The system of claim 8, wherein the one or more sensors include flow rate sensors configured to measure flow rate of the portion of the exhaled gas in the one or more breaths. ### Claim 10 (depends on 1) The system of claim 1, wherein: the CO2 monitor comprises a plurality of sensors configured to output signals related to one or more breathing parameters of the subject during one or more breaths; and the one or more physical processors are further configured to determine the second concentration measurements CO2 in the exhaled gas by the subject based on the one or more breathing parameters of the subject. ### Claim 11 (depends on 10) The system of claim 10, wherein the one or more sensors include flow rate sensors configured to measure flow rate of the exhaled gas in the one or more breaths. ### Claim 12 (depends on 1) The system of claim 1, wherein the metabolic monitor comprises one or more of a O2 sensor, and/or a CO2 sensor. ### Claim 13 (depends on 1) The system of claim 1, wherein the CO2 monitor comprises one or more of a CO2 sensor, and/or flow rate sensor. ### Claim 14 A method for metabolic measurements, the method comprising: determining, with a metabolic monitor, first concentration measurements of O2 and CO2 in a portion of gas exhaled by a subject during the one or more breaths; determining, with the metabolic monitor, a first rate of O2 consumption (VO2) and a first CO2 volume production (VCO2) of the subject during the one or more breaths based on the determined first O2 concentration in the portion of the exhaled gas and the determined first CO2 concentration in the portion of the exhaled gas; determining, with a CO2 monitor, second CO2 concentration measurements in the gas exhaled by the subject during the one or more breaths; determining, with the CO2 monitor, second CO2 volume production (VCO2) of the subject during the one or more breaths based on the measured second CO2 concentration; determining, with one or more physical computer processors (20), a correction factor based on the determined first VCO2; and the second VCO2; and determining, with one or more physical computer processors, a corrected first VO2 using the correction factor and the first VO2. ### Claim 15 (depends on 14) The method of claim 14, wherein the correction factor is determined as a quotient of the second VCO2 from the CO2 monitor and the first VCO2 from the metabolic monitor. ### Claim 16 (depends on 14) The method of claim 14, wherein the corrected first VO2 is a product of the correction factor and the first VO2. ### Claim 17 (depends on 14) The method of claim 14, wherein the CO2 monitor is a capnograph configured to continuously measure CO2 concentration in exhaled gas. ### Claim 18 (depends on 14) The method of claim 14, further comprising: determining, with one or more physical computer processors, a corrected first VCO2 using the correction factor and the determined first VCO2. ### Claim 19 (depends on 18) The method of claim 18, further comprising: determining, with one or more physical computer processors, a metabolic status of the subject based on the corrected first VO2 and the corrected first VCO2. ### Claim 20 (depends on 18) The method of claim 18, further comprising: determining, with one or more physical computer processors, energy expenditure (EE) and/or respiratory quotient (RQ) based on the corrected first VO2 and corrected first VCO2. ### Claim 21 (depends on 14) The method of claim 14, further comprising: providing, with a plurality of sensors in the metabolic monitor, output signals related to one or more breathing parameters of the subject during one or more breaths; and determining, with one or more processors, the first concentration measurements of O2 and CO2 of the portion of the exhaled gas by the subject based on the output signals from the sensors. ### Claim 22 (depends on 21) The method of claim 21 wherein the one or more sensors include flow rate sensors configured to measure flow rate of the portion of the exhaled gas in the one or more breaths. ### Claim 23 (depends on 14) The method of claim 14, further comprising: providing, with a plurality of sensors in the CO2 monitor, output signals related to one or more breathing parameters of the subject during one or more breaths; and determining, with one or more processors, the second concentration measurements CO2 in the exhaled gas by the subject based on the output signals from the sensors.