# US 12,108,954 B2 · Adhesion promotion device > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,108,954 B2 - Document ID: US12108954B2 - Status: Granted - Kind: B2 - Application number: 17/487,463 - Filed: 2021-09-28 - Published: 2022-01-13 - Granted: 2024-10-08 - Earliest claimed: 2019-03-28 - Assignees: Terumo Kabushiki Kaisha - Applicants: Terumo Kabushiki Kaisha - Inventors: Yuu Oosawa; Yuuki Hara; Wataru Karino; Naotaka Chino; Kei Honda; Takayuki Uchida; Masaru Ikegami; Xiaowei Lu - Web page: https://patentgrep.com/patent/US12108954B2 ## CPC - A61B 17/07292: {Reinforcements for staple line, e.g. pledgets} - A61B 17/1155: {Circular staplers comprising a plurality of staples} - A61B 17/085: {with adhesive layer} - A61B 2017/00884: {enhancing wound closure} - A61F 2/0063: {Implantable repair or support meshes, e.g. hernia meshes} - A61F 2220/0016: with sharp anchoring protrusions, e.g. barbs, pins, spikes - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) ## Abstract An adhesion promotion device is disclosed, which is capable of reducing risk factors of an anastomotic leakage after surgery. The adhesion promotion device has a main body portion disposed between biological organs serving as a joint object. The main body portion has a first region and a second region formed along an outer edge of the first region. The second region includes an adhesion promotion portion that promotes adhesion of a biological tissue. The first region includes a holding portion having a holding force with respect to the biological tissue which is stronger than that of the adhesion promotion portion. ## Claims ### Claim 1 An adhesion promotion device, the adhesion promotion device comprising: a main body portion configured to be disposed between biological organs serving as an object to be joined, the main body portion including a first region and a second region, the second region formed along an outer edge of the first region; the second region includes an adhesion promotion portion configured to promote adhesion of a biological tissue; and the first region includes a holding portion having a holding force with respect to the biological organs which is stronger than that of the adhesion promotion portion. ### Claim 2 (depends on 1) The adhesion promotion device according to claim 1, wherein the holding portion is integrally formed at a portion of an outer surface of the main body portion. ### Claim 3 (depends on 1) The adhesion promotion device according to claim 1, wherein the holding portion is separate from the main body portion, and is connected to a portion of the outer surface of the main body portion while covering the portion of the outer surface of the main body portion. ### Claim 4 (depends on 1) The adhesion promotion device according to claim 1, wherein the holding portion includes at least one projection. ### Claim 5 (depends on 1) The adhesion promotion device according to claim 1, wherein the main body portion further has an insertion portion formed of an elastic member, and the insertion portion further has an insertion hole into which a medical instrument is inserted. ### Claim 6 (depends on 1) The adhesion promotion device according to claim 1, wherein the main body portion is configured to be disposed in one joint target site of the biological organs serving as the object to be joined; the second region is configured to be joined to the biological tissue by a medical instrument including a first engagement instrument configured to be disposed in one joint site of the biological organs and a second engagement instrument configured to be disposed in an other joint target site of the biological organs and facing the first engagement instrument; and when the main body portion is configured to be joined to the biological tissue by the first engagement instrument and the second engagement instrument, the first region is located inward of a region where the first engagement instrument and the second engagement instrument face and overlap each other across the main body portion. ### Claim 7 (depends on 1) The adhesion promotion device according to claim 1, wherein the first region includes an adhesion promotion portion formed of a biodegradable sheet having a plurality of through-holes that pass through the first region and configured to promote adhesion of a biological tissue. ### Claim 8 (depends on 1) The adhesion promotion device according to claim 1, wherein the second region is formed of a biodegradable sheet having a plurality of through-holes that pass through the second region and configured to be promote the adhesion of the biological tissue. ### Claim 9 (depends on 1) The adhesion promotion device according to claim 1, wherein the holding portion has a friction portion configured to be disposed in the biological organs, the friction portion including a coating agent to which a particulate substance is added to generate a sliding resistance with respect to the biological organ serving as the object to be joined. ### Claim 10 An adhesion promotion device configured to promote adhesion between biological tissue, the adhesion promotion device comprising: a main body portion made of biodegradable sheet configured to promote adhesion of the biological tissue, the main body portion configured to be disposed between biological organs serving as an object to be joined, the main body portion including a first region and a second region, the second region formed along an outer edge of the first region; the second region being formed of a biodegradable sheet having a plurality of through-holes that pass through the second region and includes an adhesion promotion portion configured to promote adhesion of a biological tissue; and the first region includes one or more projections having a holding force with respect to the biological organs which is stronger than that of the adhesion promotion portion. ### Claim 11 (depends on 10) The adhesion promotion device according to claim 10, wherein the holding portion is integrally formed at a portion of an outer surface of the main body portion. ### Claim 12 (depends on 10) The adhesion promotion device according to claim 10, wherein the holding portion is separate from the main body portion, and is connected to a portion of the outer surface of the main body portion while covering the portion of the outer surface of the main body portion. ### Claim 13 (depends on 10) The adhesion promotion device according to claim 10, wherein the main body portion further has an insertion portion formed of an elastic member, and the insertion portion further has an insertion hole into which a medical instrument is inserted. ### Claim 14 (depends on 10) The adhesion promotion device according to claim 10, wherein the main body portion is configured to be disposed in one joint target site of the biological organs serving as the object to be joined; the second region is configured to be joined to the biological tissue by a medical instrument including a first engagement instrument configured to be disposed in one joint site of the biological organs and a second engagement instrument configured to be disposed in an other joint target site of the biological organs and facing the first engagement instrument; and when the main body portion is configured to be joined to the biological tissue by the first engagement instrument and the second engagement instrument, the first region is located inward of a region where the first engagement instrument and the second engagement instrument face and overlap each other across the main body portion. ### Claim 15 (depends on 10) The adhesion promotion device according to claim 10, wherein the first region includes an adhesion promotion portion formed of a biodegradable sheet having a plurality of through-holes that pass through the first region and configured to promote adhesion of a biological tissue. ### Claim 16 A method of promoting adhesion between biological tissue comprising: disposing an adhesion promotion device including a sheet-shaped main body portion that promotes the adhesion of the biological tissue between one joint target site and an other joint target site of an object to be joined of the biological organ; and joining the one joint target site and the other joint target site to each other in a state where at least a portion of the main body portion of the adhesion promotion device is disposed between the one joint target site and the other joint target site, wherein the main body portion includes a first region and a second region, the second region formed along an outer edge of the first region, and the second region includes an adhesion promotion portion that promotes adhesion of a biological tissue; and the first region includes a holding portion having a holding force with respect to the biological organs which is stronger than that of the adhesion promotion portion. ### Claim 17 (depends on 16) The method according to claim 16, further comprising: disposing the adhesion promotion device between a mouth portion periphery of a large intestine and an intestinal wall of the large intestine; moving the mouth portion periphery of the large intestine and the intestinal wall of the large intestine to be relatively closer to each other; placing the main body portion of the adhesion promotion device between the mouth portion periphery of the large intestine and the intestinal wall of the large intestine; joining the mouth portion periphery of the large intestine and the intestinal wall of the large intestine to each other in a state where the main body portion of the adhesion promotion device is placed between the mouth portion periphery of the large intestine and the intestinal wall of the large intestine; and causing the main body portion of the adhesion promotion device to indwell between the mouth portion periphery of the large intestine and the intestinal wall of the large intestine. ### Claim 18 (depends on 16) The method according to claim 16, wherein the holding portion is integrally formed at a portion of an outer surface of the main body portion. ### Claim 19 (depends on 16) The method according to claim 16, wherein the holding portion is separate from the main body portion, and is connected to a portion of the outer surface of the main body portion while covering the portion of the outer surface of the main body portion.