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US 12,104,198 B2Granted
Restoring function of tumour acidified T cells
AssigneeHelix BioPharma Corporation
InventorsWah Yau Wong, Baomin Tian, Kim Gaspar, Marni Diane Uger, Sven Rohmann, Heman Lap Man Chao
Life of this patent
Estimating the term…
Abstract
Methods and compositions to restore function to acidified T cells are provided. The methods comprise administering urease to the T cells. Compositions comprise urease.
Claims17
A method for decreasing PD-L1 expression on a PD-L1+ cancer cell, the method comprising:
- administering a composition of urease to the cancer cell, wherein the decreased PD-L1 expression minimizes detrimental cancer cell interaction with T cells.
A method for decreasing PD-L1 expression on a CEACAM6+ and/or PD-L1+ cancer cell in a solid tumor, the method comprising administering urease to the solid tumor.
Dependencies are inferred from the claim text.