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US 12,104,197 B2Granted
Prostaglandin production method
AssigneeKyowa Pharma Chemical Co., Ltd.
InventorsEitora Yamamura, Jun Ogawa, Akinori Ando
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Abstract
A prostaglandin production method according to the present invention comprises reacting an unsaturated fatty acid with cyclooxygenase in the presence of a reducing agent. According to the present invention, it is possible to produce prostaglandins at a high yield.
Claims9
A prostaglandin production method, comprising a step of reacting an unsaturated fatty acid with cyclooxygenase in a presence of a reducing agent at a pH of 8 to 12,
- wherein the reducing agent is one or more reducing agents selected from the group consisting of a divalent Sn reducing agent and KI,
- wherein the step of reacting an unsaturated fatty acid with cyclooxygenase in a presence of a reducing agent at a pH of 8 to 12 comprises:
- (i) adding the reducing agent and then the unsaturated fatty acid in sequential order to the cyclooxygenase or
- (ii) adding the unsaturated fatty acid and then the cyclooxygenase in sequential order to the reducing agent;
- and,
- wherein the method selectively produces prostaglandin Fs over prostaglandin Gs.
3 more elements
Dependencies are inferred from the claim text.