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US 12,104,176 B2Granted
Efficient cell culture system for hepatitis C virus genotype 6A
AssigneeHvidovre Hospital
InventorsJens Bukh, Long Van Pham, Santseharay Ramirez Almelda, Judith Margarete Gottwein, Yi-Ping Li, Jannie Pedersen
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Abstract
The present invention relates to nucleic acid sequences that encode hepatitis C viruses (HCV) of genotype 6a that are useful in the fundamental research of HCV as well as in the search of antivirals and vaccines against HCV. In particular, the present invention relates to nucleic acid sequences that comprises HCVs, which are capable of expressing said virus when transfected into cells and are capable of replication or infectivity in cultured cells.
Claims14
An isolated nucleic acid molecule, which encodes human hepatitis C virus of genotype 6a,
- strain HK2, wherein said molecule encodes an amino acid sequence with a sequence identity of at least 95% to that of SEQ ID NO:
- 3 and wherein the said molecule comprises the following adaptive mutations I774M, R945G, Q1024R, P1117L, V1279A, T1291N, T1370I, L1387R, S1470G, A1673S, V1825A, D2424G, N2805D, V2854M, A2927T, D2987G and Y2989F with reference to SEQ ID NO:
- 62, or
- strain HK6a, wherein said molecule encodes an amino acid sequence with a sequence identity of at least 95% to that of SEQ ID NO:
- 4 and wherein said molecule comprises the following adaptive mutations F350S, N417T, V775M, P1118L, N1283T, T1292N, S1312P, A1674S, D2425G, N2806D, E2869G, A2928T, D2988G and Y2990F with reference to SEQ ID NO:
- 63.
3 more elements
Dependencies are inferred from the claim text.