Chiral resolution method mimicking magnetic beneficiation and the magnetic nano-inhibitors for selective enrichment

A core-shell nanocomposite, which is formed by co-assembly of an amphiphilic polymer and hydrophobically modified magnetic nanoparticles, with a hydrophobically modified magnetic nanomaterial as its core and the amphiphilic polymer as its shell,

• wherein hydrophilic segments in the amphiphilic polymer are located at an outermost layer of the shell;
• wherein a crosslinking reaction is carried out between the hydrophilic segments to form a cross-linked shell;
• wherein the hydrophilic segments in the amphiphilic polymer are at least one selected from the group consisting of the following structural formulas:
• wherein R2 in formulas a-c is a functional group capable of being adsorbed on a crystal surface of a crystal to be resolved through non-covalent bond interaction, thus inhibiting crystallization and the following enrichment to promote nucleation;
• wherein R1 in formula a is at least one selected from the group consisting of methyl and hydrogen atoms;
• wherein the hydrophobic segments in the amphiphilic polymer comprise at least one polymer selected from the group consisting of hydrophobic polymers, block copolymers comprising repeating units of the hydrophobic polymers, random comprising repeating units of the hydrophobic polymers, graft copolymers comprising repeating units of the hydrophobic polymers, and hyperbranched polymers comprising repeating units of the hydrophobic polymers;
• further wherein the hydrophobic polymers comprise least one polymer selected from the group consisting of polystyrene, polyethylene, polypropylene, polybutadiene, polyisoprene, polydimethylsiloxane, polymethylhydrosiloxane, polymethacrylate, polymethacrylamide, polyamide, polyimide, polyformaldehyde, polycarbonate, cellulose, and derivatives thereof;
• and
• wherein in formulas a-c, m represents the polymerization degree of the hydrophilic segments and ranges from 10 to 60.