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US 12,103,954 B2Granted
Heterodimeric Fc cytokines and uses thereof
AssigneeSynthekine, Inc.
InventorsPatrick Lupardus, Deepti Rokkam
Life of this patent
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Abstract
The present disclosure provides IL12 and IL23 muteins as partial agonists comprising modified human p40 molecules that associate with human p35 (hP35) and human P19 (hP19) to form modified hIL-12 and IL23 partial agonists wherein the individual components of IL12 and IL23 muteins are linked to engineered Fc domains.
Claims15
A heterodimeric hIL12Fc mutein, the heterodimeric hIL12Fc mutein comprising a first polypeptide having the sequence of any one of SEQ ID NOS:
- 80, 83, 85, 86, 88, 90, 92, 121, 129, 132, 135, 138, 141, 144, 147, 150, and 153;
- and
- a second polypeptide having the sequence of any one of SEQ ID NOS:
- 81, 82, 84, 87, 89, 91, 93, and 124.
1 more element
Dependencies are inferred from the claim text.