Radiation-activatable platinum complex, its preparation and therapeutic use

A platinum complex comprising a structure of Formula (I):

• wherein:
• X, X′, Y, Y′ and Z are independently selected from the group consisting of ammonia, hydroxide, halide, oxalate, diamines, dicarboxylate, glycolate and —OR, optionally X and X′ are linked to form a first bidentate ligand, and/or Y and Y′ are linked to form a second bidentate ligand;
• n is selected from the group consisting of zero, any positive charge, and any negative charge;
• R is a radiation-responsive moiety having a structure of Formula (II):
• with L being a linker group being selected from the group consisting of:
• wherein p is selected from the group consisting of of 1, 2, 3 and 4, and R10 is selected from the group consisting of H, a linear C1-C6 alkyl group, a branched C1-C6 alky group, and a functional side chain;
• m is 0, 2 or 3;
• R1 and R8 are independently selected from the group consisting of a linear or branched alkyl chain, a sulfonate-containing group, a carboxyl group, a carboxylate ester-containing group, and a heterocyclic group;
• and
• R2 to R7 are each independently selected from the group consisting of a hydrogen, a halogen, and an adjacent pair of R2 to R7 forming a fused 6-membered carbocyclic ring.