Back to results
US 12,103,930 B2Granted
Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid
AssigneeMerck & Cie
InventorsRudolf Moser, Viola Groehn, Thomas Egger, Thomas Ammann
Life of this patent
Estimating the term…
Abstract
The invention is directed towards stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid and its hemisulfate salt as well as pharmaceutical compositions and uses thereof in therapy, preferably chemotherapy.
Claims10
A method for treating cancer selected from the group consisting of breast cancer, esophageal cancer, gastric cancer, gall bladder cancer, bile duct cancer, colon cancer, rectal cancer, colorectal cancer, osteosarcoma, liver cancer, pancreatic cancer, ovarian cancer, head and neck cancer and mesothelioma cancer,
- which treatment does not include prevention,
- comprising administering an effective amount of a reconstituted solution to a patient in need thereof in conjunction with at least one further chemotherapeutic agent suitable for the treatment of cancer,
- wherein the reconstituted solution is from a lyophilized product that has been prepared from a stable pharmaceutical composition comprising a hemisulfate salt of 5,10-methylene-(6R)-tetrahydrofolic acid having a pH of 5 to 10.5, which composition has been lyophilized, and which lyophilized product has been reconstituted by water or a liquid pharmaceutically acceptable vehicle.
Dependencies are inferred from the claim text.