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US 12,103,913 B2Granted
Spirobiindane derivatives and a process for preparation thereof
AssigneeReliance Industries Limited
InventorsVirendrakumar Gupta, Parthiv Mukundkumar Trivedi
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Abstract
The present disclosure relates to spirobiindane derivatives and a process for preparation of the same. Spirobiindane derivatives are used as intermediates for many commercially important compounds such as chiral polymers. The present disclosure provides a simple and economical process for the preparation of spirobiindane derivatives of Formula (I) with high yield and having high purity.
Claims7
A process for preparation of a spirobiindane derivative of Formula I;
- wherein,
- R1 is selected from the group consisting of —COOCnH(2n+1), where n=2, and —COPh,
- wherein said process comprising
- a. reacting 3,3,3′,3′-tetramethyl-2,2′,3,3′-tetrahydro-1,1′-spirobiindane-5,5′,6,6′-tetraol, represented as Formula II
- with a protecting agent and pyridine as a base in a first fluid medium at a predetermined temperature for predetermined time period to obtain a resultant comprising a crude spirobiindane derivative and unreacted pyridine;
- b. separating said unreacted pyridine from said resultant to obtain a crude spirobiindane derivative;
- and
- c. crystallizing said crude spirobiindane derivative using at least one second fluid medium to obtain crystals of spirobiindane derivative of Formula I having purity greater than 95%;
- wherein the mole ratio of said compound of Formula II and pyridine is in the range of 1:5 to 1:15.
6 more elements
Dependencies are inferred from the claim text.