# US 12,103,910 B1 · Process for making selective organoselenium-based ligands

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- Number: US 12,103,910 B1
- Document ID: US12103910B1
- Status: Granted
- Kind: B1
- Application number: 18/244,938
- Filed: 2023-09-12
- Published: 2024-09-12
- Granted: 2024-10-01
- Earliest claimed: 2023-02-23
- Assignees: King Faisal University
- Applicants: King Faisal University
- Inventors: Hany Mohamed Abd El-Lateef Ahmed; Saadeldin Elsayed Ibrahim Shabaan; Mai Mustafa Khalaf Ali; Mohamed Gouda; Wael I. Mortada
- Web page: https://patentgrep.com/patent/US12103910B1

## CPC

- C07C 391/02: having selenium atoms bound to carbon atoms of six-membered aromatic rings
- C07C 1/00: Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
- G01N 1/4044: {by chemical techniques; Digestion; Chemical decomposition}
- G01N 33/1813: {Specific cations in water, e.g. heavy metals}
- Y10T 436/107497: Preparation composition [e.g., lysing or precipitation, etc.]
- Y10T 436/255: including use of a solid sorbent, semipermeable membrane, or liquid extraction
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

Novel organoselenium selective ligands are presented and designed to determine metal ions in a sample. These ligands are used as complexing agents in a dispersive liquid-liquid microextraction procedure of copper and zinc ions. The procedure has a shortened extraction time, minimal organic solvent types, and lower amounts of solvents, as well as easy operation and high enrichment efficiency.

## Claims

### Claim 1

A process for making an organoselenium compound, comprising reacting a diselenide compound of the formula:
with R—Br in the presence of ethanol, NaBH4, and N2 to obtain a compound of the formula:
which compound in turn is reacted with, in the presence of toluene, a compound of the formula:
wherein
each X is the same and is hydrogen, fluorine, chlorine, or bromine; and
R is ethyl or phenethyl, wherein the organoselenium compound is selected from the group consisting of: