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US 12,102,790 B2Granted
Connected drug delivery system for erythropoietin stimulating agents
AssigneeFresenius Medical Care Holdings, Inc.
InventorsDavid Yuds, Sameer Peesapati
Life of this patent
Estimating the term…
Abstract
Methods to treat anemia are provided whereby an erythropoietin stimulating agent (ESA) and an iron supplement are administered by a wearable device, based on patient parameters sensed by the wearable device. The method can involve monitoring patient parameters and dosing an ESA and an iron supplement in real-time, via the wearable device.
Claims19
A wearable device, the device comprising:
- a housing configured to be attached to the skin of a patient during use;
- a first drug reservoir within the housing, containing an amount of a first drug;
- a second drug reservoir within the housing, containing an amount of a second drug, the first drug and the second drug being interdependent on one another;
- an injector assembly at least partially housed in the housing and configured to inject (1) a first drug into the patient, through the patient's skin, and (2) the second drug into the patient, through the patient's skin, the first drug reservoir being in fluid communication with the injector assembly, and the second drug reservoir being in fluid communication with the injector assembly;
- a first sensing system configured to sense one or more patient parameters that are indicative of a need to administer the first drug to the patient, the first sensing system comprising one or more sensors and a control signal generator, the control signal generator being configured to generate a control signal in response to the one or more patient parameters that are sensed;
- a second sensing system configured to sense one or more patient parameters that are indicative of a need to administer the second drug to the patient, the second sensing system comprising one or more second sensors and a second control signal generator, the second control signal generator being configured to generate a second control signal in response to the one or more patient parameters that are sensed by the second sensing system;
- a control system within the housing and configured to receive control signals from the first sensing system and from the second sensing system, and, based on the control signals received, activate the injector assembly to (i) inject the first drug into the patient, (ii) inject the second drug into the patient, or (iii) inject both the first drug and the second drug into the patient;
- a first drug level sensor configured to sense the amount of the first drug in the first drug reservoir and to generate a first drug supply signal;
- a second drug level sensor configured to sense the amount of the second drug in the second drug reservoir and to generate a second drug supply signal;
- and
- a transmitter, in the wearable device, configured to transmit the first drug supply signal and the second drug supply signal to a remote device.
8 more elements
A wearable device comprising:
- a housing configured to be attached to the skin of a patient during use;
- an injector assembly at least partially housed in the housing and configured to inject (1) a first drug into the patient, through the patient's skin, and (2) a second drug into the patient, through the patient's skin;
- a first sensing system configured to sense one or more patient parameters that are indicative of a need to administer the first drug to the patient, the first sensing system comprising one or more sensors and a control signal generator, the control signal generator being configured to generate a control signal in response to the one or more patient parameters that are sensed;
- and
- a control system within the housing and configured to receive a control signal from the first sensing system and, based on a control signal received, activate the injector assembly to inject the first drug into the patient, wherein
- the wearable device is configured for the management of anemia, the first drug comprises erythropoietin, the control system comprises a microprocessor and a memory, the first sensing system comprises a pulse oximeter, a hemoglobin sensor, and a blood pressure sensor, the memory has stored therein a three-dimensional matrix of evaluation triplets and assigns to each evaluation triplet a value corresponding to a required change in a rate of injection of erythropoietin, and the control system is configured to:
- (1) calculate a first evaluation quantity (O2 Sat) based on an amount of blood oxygen sensed by the pulse oximeter;
- (2) calculate a second evaluation quantity (Hemo) based on a level of hemoglobin sensed by the hemoglobin sensor;
- (3) calculate a third evaluation quantity (BP) based on a blood pressure sensed by the blood pressure sensor;
- (4) form an evaluation triplet (O2 Sat/Hemo/BP) from the first evaluation quantity, the second evaluation quantity, and the third evaluation quantity;
- and
- (5) compare the evaluation triplet to evaluation triplets stored in the memory;
- and
- (6) regulate a rate of injection of erythropoietin by changing the rate of injection of erythropoietin by a value corresponding to the required change value stored in the memory and corresponding to the evaluation triplet formed.
11 more elements
Dependencies are inferred from the claim text.