Polyurethane based medical articles

A medical article formed from a polyurethane-based resin, which is a reaction product of ingredients comprising:

• a diisocyanate comprising 4,4′-diphenylmethane diisocyanate (MDI);
• a diol chain extender comprising 1,4-butanediol;
• a polyglycol comprising polytetramethylene ether glycol;
• and
• a zwitterionic modifier or a combination of anionic and cationic modifiers incorporated into a backbone, as a side chain, or both of the polyurethane-based resin formed by the diisocyanate, the polyglycol, and the diol chain extender, the cationic modifier comprising bis(2-hydroxyethyl)dimethylammonium chloride (BHDAC), the anionic modifier comprising bis-1,4-((2-hydroxypropoxy)-2-propoxy)-butane sulfonate sodium salt, or 2,2-bis(hydroxymethyl) butyric acid (BHMBA) and bis-1,4-((2-hydroxypropoxy)-2-propoxy)-butane sulfonate sodium salt;
• the polyurethane-based resin having a hard segment content in a range of from 25% to 75% by weight and a soft segment content of the resin is in a range of from 75% to 25% by weight.

A medical article formed from a polyurethane-based resin, which is a reaction product of ingredients comprising:

• a diisocyanate comprising 4,4′-diphenylmethane diisocyanate (MDI);
• a diol chain extender comprising 1,4-butanediol;
• a polyglycol comprising a polytetramethylene ether glycol;
• and
• a zwitterionic modifier or a combination of anionic and cationic modifiers incorporated into a backbone, as a side chain, or both of the polyurethane-based resin formed by the diisocyanate, the polyglycol, and the diol chain extender, the cationic modifier comprising bis(2-hydroxyethyl)dimethylammonium chloride (BHDAC), the anionic modifier comprising one or more of bis-1,4-((2-hydroxypropoxy)-2-propoxy)-butane sulfonate sodium salt, 2,3-dihydroxypropane-1-sulfonate sodium salt, N,N-bis(2-hydroxyethyl)-2-aminoethanesulfonate sodium salt, 2,2-bis(hydroxymethyl) propionic acid, or 2,2-bis(hydroxymethyl) butyric acid (BHMBA), and the zwitterionic modifier comprising N, N-bis(2-hydroxyethyl)-2-amino-ethanesulfonic acid, or a combination of N,N-bis(2-hydroxyethyl)-2-amino-ethanesulfonic acid and N,N-bis(2-hydroxyethyl)glycine;
• the polyurethane-based resin having a hard segment content in a range of from 25% to 75% by weight and a soft segment content of the resin is in a range of from 75% to 25% by weight.