Napped coated wound dressing

An absorbable tissue adhesive wound dressing comprising a melt-blown porous matrix substrate comprising a plurality of absorbable bonded melt-blown sheets having a tissue-facing surface that is napped at the surface for high tissue adhesion and coated with a coating layer that is oriented to be applied directly onto a tissue, said layer comprising co-reactive hydrogel-forming materials, applied sequentially or as a mixture,

• wherein
• (i) napping of the tissue-facing surface disrupts the coating layer relative to non-napped conditions, prevents blocking the microporous structure of the matrix substrate, and improves coating of individual fibers and better penetration into the matrix substrate,
• (ii) upon contact with bodily fluids, the fluids wick into and migrate through the matrix substrate,
• (iii) the wound dressing comprises a highly-adhesive hemostatic patch comprised of the napped melt-blown matrix substrate in combination with a cross-linkable coating that results in enhanced tissue adhesion,
• (iv) the napped surface results in both higher amount of coated fibers and greater surface roughness, that together enhance adhesion at the patch-tissue interface with structural integration of the hemostatic patch with tissue for enhanced adhesion, and
• (v) a first hydrogel-forming material is having two or more nucleophilic functional groups that react with an electrophilic functional group on a second hydrogel-forming material to form a covalent bond upon contact with the tissue.