ROS-responsive liposomes for specific targeting
AssigneeVerily Life Sciences LLC
InventorsKimberly Kam, Zhan Wang, Stephen Morton, Nicole Peck
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Abstract
Provided herein are encapsulated liposomes comprising a lipid bilayer, a first polyethylene glycol (PEG) corona, a targeting molecule and a second PEG corona. The second, encapsulating PEG corona can be reversibly linked to the first PEG corona. Also provided are pharmaceutical compositions comprising the encapsulated liposomes and methods of treating a subject with a disease characterized by production of reactive oxygen species (ROS) with the compositions. Also provided are methods of making the encapsulated liposomes disclosed herein.
Claims4
A method of treating a subject, the method comprising:
- administering to the subject a pharmaceutical composition, wherein the subject has cancer characterized by production of reactive oxygen species and wherein the pharmaceutical composition comprises:
- an encapsulated liposome comprising:
- a lipid bilayer with a first polyethylene glycol (PEG) corona, wherein the first PEG corona further comprises a targeting molecule,
- a second PEG corona reversibly linked to the first PEG corona, wherein the reversible links comprise a boronic ester bond, and
- one or more active agents, wherein at least one of the one or more active agents is a chemotherapeutic agent;
- and
- a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.