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US 12,102,673 B2Granted
Zika virus vaccine
AssigneeValneva Austria GmbH
InventorsJana Barbero Calzado, Mario Nebenführ, Robert Schlegl, Michael Weber, Jürgen Heindl-Wruss
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Abstract
Described herein are Zika virus vaccines and compositions and methods of producing and administering said vaccines to subjects in need thereof.
Claims32
A Zika virus vaccine comprising a Zika virus having an RNA genome, wherein said Zika virus vaccine is capable of stimulating a neutralizing antibody titer greater than 15 in at least 70% of vaccinated subjects, wherein the neutralizing antibody titer is determined using a microneutralization assay (MN50) following a single administration of the Zika virus vaccine to a subject;
- and wherein the Zika virus comprises an E protein having an amino acid sequence having at least 95% sequence identity to any one of SEQ ID NOs:
- 14-69 and is able to pack a virulent Zika virus.
Dependencies are inferred from the claim text.