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US 12,102,667 B2Granted
Polypeptides and antibiotics against gram-negative bacterium comprising the same
AssigneesLysentech, Hankuk University of Foreign Studies Research & Business Foundation
InventorsHeejoon Myung, Min Soo Kim, Hye-Won Hong, Young Deuk Kim, Jaeyeon Jang
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Abstract
Provided are a novel polypeptide having endolysin activity, a fusion protein comprising the polypeptide and an antibiotic active protein, and an antibiotic use against a gram-negative pathogen of the polypeptide and/or fusion protein and/or a use for prevention and/or treatment of gram-negative pathogen infection and/or disease or symptoms related to gram negative pathogen infection.
Claims19
A polypeptide, comprising the amino acid sequence of SEQ ID NO:
- 2, wherein
- 1) the 39th residue in the amino acid sequence of SEQ ID NO:
- 2 is substituted with serine;
- 2) the 43rd residue in the amino acid sequence of SEQ ID NO:
- 2 is substituted with histidine;
- 3) the amino acid corresponding to the 45th residue in the amino acid sequence of SEQ ID NO:
- 2 is substituted with glutamic acid;
- 4) the amino acid corresponding to the 73rd residue in the amino acid sequence of SEQ ID NO:
- 2 is substituted with valine;
- 5) the amino acid corresponding to the 101st residue in the amino acid sequence of SEQ ID NO:
- 2 is substituted with alanine;
- and
- 6) the amino acid corresponding to the 113rd residue in the amino acid sequence of SEQ ID NO:
- 2 is substituted with valine.
11 more elements
Dependencies are inferred from the claim text.