Mammal-specific growth-defective arbovirus
AssigneeTenGen Biomedical Company
InventorsXiaowu Pang, Xinbin Gu
Life of this patent
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Abstract
Arbovirus carries an altered furin cleavage site that results in enhanced cleavage of a precursor polyprotein, such as, prE2 or prM. Dengue virus particles can have an amino acid alteration within amino acids 80-130 of prM. Zika virus particles can have alterations at amino residues at and/or about the furin cleavage site. The virus can be produced in insect cells. The virus does not form progeny virus in mammal cells.
Claims13
A Dengue serotype 2 virus particle comprising a growth-restricted particle comprising a dysfunctional furin tetrapeptide recognition site in a precursor polyprotein, wherein said site comprises Arg-Arg-Lys/Arg-Arg (SEQ ID NO:
- 16), and wherein said growth-restricted particle does not replicate in mammal cells.
Dependencies are inferred from the claim text.