Use of germ cells for preparing a micro hair follicle
AssigneeL'oreal
InventorsTheebah Sellathurai, Khalid Bakkar
Life of this patent
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Abstract
The invention relates to the use of germ cells for obtaining a micro hair follicle and to the use thereof for evaluating the effect of cosmetic, pharmaceutical or dermatological products and also for the prophylactic or therapeutic treatment of a state of reduced pilosity.
Claims12
An in vitro process for preparing a micro hair follicle, comprising amplifying germ cells isolated from the bulge of a hair follicle in the telogen phase to obtain keratinocytes positive for CD200, CD29 and K15 markers in the presence of a ROCK inhibitor and then at least one step of culturing the keratinocytes positive for CD200, CD29 and K15 markers for a period of time sufficient to allow differentiation into a tubular structure of said keratinocytes positive for CD200, CD29 and K15 markers being brought into contact with the connective tissue sheath fibroblasts and/or dermal papilla fibroblasts.
Dependencies are inferred from the claim text.