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US 12,098,380 B2Granted
Vero cell lines stably expressing HSV ICP0 protein
AssigneeThe Brigham and Women's Hospital, Inc.
InventorFeng Yao
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Abstract
Provided herein are Vero cell lines that stably express Herpes Simplex Virus (HSV) ICP0 protein. These cells have the same morphology of Vero cells, exhibit stable expression of HSV ICP0 protein, and also efficiently complement replication of HSV ICP0 deficient virus for greater than 20, 30, or even 40 cell passages.
Claims18
A Vero cell line comprising a nucleotide sequence that encodes for a Herpes Simplex virus (HSV) ICP0 protein operably linked to a promoter, wherein the promoter comprises SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.