Cell culture and tissue engineering systems with controlled environmental zones
AssigneeOctane Biotech Inc.
InventorsGuy Oram, Taylor Plant, Ian Grant, Timothy Smith
Life of this patent
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Abstract
An automated cell culture and tissue engineering system comprising defined and separate environmental zones provide for increased control and maintenance of the internal environment of the system such that the temperature, air flow and gases surrounding the bioreactor module form one zone that is maintained separately to a second zone formed surrounding the reagent fluid reservoir. The system further comprises means for elimination and/or management of condensation within the second zone of the system.
Claims19
A method for preparing a controlled thermal environment for biological processes within an automated cell culture cassette, the automated cell culture cassette comprising a bioreactor module and a reagents fluid reservoir, the method comprising:
- raising a movable thermal barrier assembly into an unlocked, raised position;
- installing the automated cell culture cassette into a housing having an outer shell cover and an inner shell body, and against an operational robotics interface positioned within the inner shell body;
- lowering the movable thermal barrier assembly into a locked, lowered position to restrain the automated cell culture cassette against the operational robotics interface and to form a portion of a lower surface boundary of a warm zone and a portion of an upper surface boundary of a cold zone;
- and
- circulating a warm airflow path surrounding the bioreactor module and a cold airflow path surrounding the reagents fluid reservoir.
A cell culture system for receiving and operationally supporting an automated cell culture cassette for biological processes,
- the automated cell culture cassette comprising a bioreactor module and a reagents fluid reservoir, the system comprising:
- a housing;
- an operational robotics interface;
- and
- a movable thermal barrier assembly having an unlocked, raised position for installing the automated cell culture cassette, and a locked, lowered position for thermally isolating a warm zone from a cold zone, the movable thermal barrier assembly operationally restraining the automated cell culture cassette against the operational robotics interface;
- and wherein, when in the locked, lowered position, the movable thermal barrier assembly forms a portion of a lower surface boundary of the warm zone and a portion of an upper surface boundary of the cold zone.
Dependencies are inferred from the claim text.