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US 12,098,286 B2Granted
Nanoprobe-metal chelator complexes
AssigneesThe General Hospital Corporation, Northeastern University
InventorsHak Soo Choi, Jonghan Kim, Georges El Fakhri
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Abstract
Provided herein are compounds that are able to bind metal ions (e.g., free metal ions or metal ions bound to low affinity ligands) in a sample or subject. Also provided herein are methods of using the compounds for chelating metal ions and for the treatment of diseases associated with abnormal levels of metal ions. Methods of preparing the compounds and pharmaceutical compositions are also provided.
Claims13
A compound of Formula I:
- A-B I
- or a pharmaceutically acceptable salt thereof, wherein:
- A is a group comprising a zwitterion selected from the group consisting of formulas A-1, A-2, A-3, A-4, A-5, and A-6:
- wherein:
- X is selected from the group consisting of a bond, CH2, NH, —NH—C1-6 alkylene-, O and S;
- each RA is an independently selected anionic group;
- each RC is an independently selected cationic group;
- and
- L1, L2, and L3 are each an independently selected C1-6 alkylene group;
- B is
- wherein:
- indicates the bond between B and A;
- and
- n is an integer from 5 to 30;
- each C is independently selected from the group consisting of H and an anionic group;
- each D is an independently selected linking group;
- and
- each E is an independently selected metal chelating group.
15 more elements
Dependencies are inferred from the claim text.