Antibodies to amyloid beta
AssigneeMedImmune, LLC
InventorsMaria Groves, Suzanne Gustavsson, Kina Höglund, Chris Lloyd, Adrian Nickson, Camilla Niva, Sylvia Simon, David Lowne, Fraser Welsh, Per-Ola Freskgard
Life of this patent
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Abstract
Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42 peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid beta 42 as therapeutic agents for binding amyloid beta 42 peptide and treating conditions associated with amyloidosis, such as Alzheimer's disease.
Claims12
An isolated antibody molecule that is selective for binding human amyloid beta 1-42 peptide (Aβ1-42) over human amyloid beta 1-40 peptide (Aβ1-40), wherein the antibody molecule comprises a VH domain having an amino acid sequence that is at least 90% identical to the amino acid sequence of SEQ ID NO:
- 524 and a VL domain having an amino acid sequence that is at least 90% identical to the amino acid sequence of SEQ ID NO:
- 533,
- wherein the VH domain of the antibody molecule comprises:
- a) HCDR1 of SEQ ID NO:
- 525, HCDR2 of SEQ ID NO:
- 526, and HCDR3 of SEQ ID NO:
- 527;
- b) wherein FW1 of the VH domain comprises:
- a methionine residue at the amino acid position corresponding to position 26 of SEQ ID NO:
- 524;
- a glycine residue at the amino acid position corresponding to position 27 of SEQ ID NO:
- 524;
- an asparagine residue at the amino acid position corresponding to position 28 of SEQ ID NO:
- 524;
- and
- an asparagine residue at the amino acid position corresponding to position 30 of SEQ ID NO:
- 524;
- and wherein the VL domain of the antibody molecule comprises LCDR1 of SEQ ID NO:
- 534, LCDR2 of SEQ ID NO:
- 535, and LCDR3 of SEQ ID NO:
- 536.
Dependencies are inferred from the claim text.