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US 12,098,173 B2Granted
Innocuous, structured scaffolds for structure-based amyloid disease vaccines and antigens
AssigneeThe Governors of the University of Alberta
InventorsHolger Wille, Jiarui Fang, José Miguel Flores-Fernández, Vineet Rathod, Xinli Tang
Life of this patent
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Abstract
The present disclosure relates generally to polypeptides, which may be used of the treatment of neurological diseases or disorders.
Claims14
An isolated recombinant polypeptide comprising or consisting of:
- a β-solenoid structured polypeptide comprising amino acids from an innocuous β-solenoid scaffold polypeptide and a plurality of epitope amino acids from a disease associated polypeptide, wherein said plurality of epitope amino acids occur at every second residue in a β-strand of said β-solenoid structured polypeptide and comprise exposed side chains that project or are configured to project to an exterior position of a β-solenoid domain of the β-solenoid structured polypeptide.
Dependencies are inferred from the claim text.