Hydantoin containing deoxyuridine triphosphatase inhibitors

A compound of Formula (I):

• or a tautomer thereof, or a deuterium isotope of each of the above wherein up to 10 hydrogen atoms that are attached to one or more carbon atoms are replaced with deuterium(s), or a pharmaceutically acceptable salt of each of the foregoing, or a pharmaceutically acceptable solvate of each of the above mentioned,
• wherein
• A is
• each R30 independently is hydrogen;
• an optionally substituted C1-C10 alkoxy;
• optionally substituted amino, an optionally substituted C1-C10 alkyl;
• optionally substituted hydroxy;
• or Z;
• L1 is —(CH2)q—, wherein one or more hydrogens are optionally substituted with C1-C3 alkyl and/or two geminal hydrogens together with the carbon to which they are attached are optionally replaced with an optionally substituted 3-5 membered heterocyclyl or an optionally substituted 3-5 membered cycloalkyl;
• and wherein q is 3, 4, 5, 6, 7, or 8;
• wherein one or more hydrogens are optionally substituted with C1-C3 alkyl and/or two geminal hydrogens together with the carbon to which they are attached are optionally replaced with an optionally substituted 3-5 membered heterocyclyl or an optionally substituted 3-5 membered cycloalkyl;
• and wherein p is 0, 1, 2, 3, 4, or 5 and z is 0, 1, 2, 3, 4, or 5;
• —(CH2)m—X15—(CH2)n—, wherein one or more hydrogens are optionally substituted with C1-C3 alkyl and/or two geminal hydrogens together with the carbon to which they are attached are optionally replaced with an optionally substituted 3-5 membered heterocyclyl or an optionally substituted 3-5 membered cycloalkyl;
• and wherein m is 1, 2, or 3 and n is 1, 2, 3, 4, 5, 6, or 7;
• or
• wherein one or more hydrogens are optionally substituted with C1-C3 alkyl and/or two geminal hydrogens together with the carbon to which they are attached are optionally replaced with an optionally substituted 3-5 membered heterocyclyl or an optionally substituted 3-5 membered cycloalkyl;
• and wherein o is 0, 1, 2, or 3;
• r is 1, 2 or 3;
• and s is 0, 1, 2, 3, or 4;
• and
• wherein X15 is NR40, O, or S, wherein R40 is H or C1-C3 alkyl;
• L2 is —SO2NR50—, wherein the sulfur is attached to L1;
• —NR50SO2—, wherein the nitrogen is attached to L1;
• —NR50C(O)—, wherein the nitrogen is attached to L1;
• —NR50SO2NR50 —;
• or —NR50CONR50—;
• each R50 independently is hydrogen, an optionally substituted C1-C6 alkyl, an optionally substituted C2-C6 heteroalkyl, an optionally substituted C2-C6 alkenyl, an optionally substituted C3-C6 heteroalkenyl, an optionally substituted C2-C6 alkynyl, an optionally substituted C3-C6 heteroalkynyl, or Z;
• Z is
• each R51 and R52 independently is hydrogen or an optionally substituted C1-C10 alkyl;
• X is an optionally substituted hydroxy group, an optionally substituted NH2 group, or an optionally substituted SH group;
• L3 is a cyclopropano group, a cyclobutano group, an optionally substituted C1-C6 alkylene, an optionally substituted C2-C6 heteroalkylene, an optionally substituted C2-C6 alkenylene, an optionally substituted C3-C6 heteroalkenylene, an optionally substituted C2-C6 alkynylene, or an optionally substituted C3-C6 heteroalkynylene;
• and
• B is an optionally substituted 6-10 membered aryl.