Compositions and methods for the treatment of cancer
AssigneeDuke University
InventorsDennis J. Thiele, Bushu Dong, Alexander M. Jaeger, Philip F. Hughes, Timothy Haystead, Jiyong Hong
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Abstract
This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to Heat Shock Transcription Factor 1 (HSF1) activity and/or function. More particularly, this disclosure relates to methods of inhibiting HSF1 activity with these compounds and pharmaceutical compositions thereof, and methods of treating diseases associated with HSF1 activity and/or function, such as cancer.
Claims7
A method of treating cancer associated with an elevated HSF1 activity in a subject in need thereof, the method comprising administering to the subject an effective amount of an HSF1 inhibiting compound selected from the group consisting of:
- and combinations thereof,
- wherein the cancer is selected from the group consisting of breast cancer, prostate cancer, colon cancer, squamous cell cancer, small-cell lung cancer, non-small cell lung cancer, ovarian cancer, cervical cancer, gastrointestinal cancer, pancreatic cancer, glioblastoma, liver cancer, bladder cancer, hepatoma, colorectal cancer, uterine cervical cancer, endometrial carcinoma, salivary gland carcinoma, mesothelioma, kidney cancer, vulval cancer, pancreatic cancer, thyroid cancer, hepatic carcinoma, skin cancer, melanoma, brain cancer, neuroblastoma, myeloma, head and neck cancer, leukemia (including but not limited to acute lymphoblastic leukemia and acute myeloid leukemia), sarcoma, carcinoma, stromal cancer, testicular cancer, neurofibroma, hepatocellular carcinoma, lymphoma, Ewing sarcoma and peripheral neuroepithelioma.
A compound having the structure of
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.