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US 12,097,300 B2Granted
Biofunctional hydrogel for wound healing
AssigneeNanyang Technological University
InventorsBee Eng Mary Chan, Chun Kiat Yeo, Nguan Soon Tan, Surendra Hittanahalli Mahadevegowda
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Abstract
Disclosed herein is a hydrogel that eradicates biofilm bacteria from wounds and accelerates diabetic wound healing. Also disclosed herein are methods of manufacture and use of said hydrogel.
Claims19
A hydrogel for wound healing comprising:
- a hydrogel polymeric matrix comprising:
- a first polymeric component;
- a second polymeric component, where the first and second polymeric components are crosslinked together to form the hydrogel polymeric matrix;
- and
- a first portion of a polymeric antimicrobial material capable of crosslinking with the first and/or second polymeric components, said first portion being wholly or partly crosslinked into the hydrogel polymeric matrix;
- a second portion of the polymeric antimicrobial material capable of crosslinking with the first and/or second polymeric components, said second portion being distributed within the hydrogel polymeric matrix but not crosslinked into the hydrogel polymeric matrix;
- wherein the first and second polymeric components are selected from one of the following sets:
- (a) the first polymeric component is derived from a polymeric material comprising at least two thiol functional groups and the second polymeric component is derived from a polymeric material comprising at least two maleimide groups;
- (b) the first polymeric component is derived from a polymeric material comprising at least two thiol functional groups and the second polymeric component is derived from a polymeric material comprising at least two vinyl sulfone groups;
- (c) the first polymeric component is derived from a polymeric material comprising at least two azide functional groups and the second polymeric component is derived from a polymeric material comprising at least two cyclooctynyl groups;
- (d) the first polymeric component is derived from a polymeric material comprising at least two amine functional groups and the second polymeric component is derived from a polymeric material comprising at least two aldehyde groups;
- and
- (e) the first polymeric component is derived from a polymeric material comprising at least two amine functional groups and the second polymeric component is derived from a polymeric material comprising at least two acrylate groups;
- and
- optionally, an antioxidant material distributed within the hydrogel polymeric matrix and/or covalently bonded thereto.
12 more elements
Dependencies are inferred from the claim text.