Cancer treatment method for magnetic hypothermia cancer treatment
AssigneeImam Abdulrahman Bin Faisal University
InventorsB. Rabindran Jermy, Vijaya Ravinayagam, Dana Almohazey
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Abstract
A nanomedicinal composition comprising a nanocarrier and a pharmaceutical agent mixture comprising an anti-cancer therapeutic and an antioxidant. The nanocarrier comprises a porous silicate matrix and particles of a magnetic ferrite disposed in the pores of the porous silicate matrix. The pharmaceutical agent mixture is disposed in the pores and/or on the surface of the nanocarrier by a solution phase impregnation process. The nanomedicinal composition is used in a method of treating breast cancer.
Claims9
A cancer treatment method for treating a subject having a breast cancer, comprising:
- administering to the subject a pharmaceutical composition comprising a nanomedicinal composition,
- exposing the subject to an alternating magnetic field after the administering, thereby raising the temperature of the nanomedicinal composition in the subject to increase a rate of release of the nanomedicinal composition and/or hyperthermially treat the breast cancer;
- wherein the nanomedicinal composition comprises:
- a nanocarrier comprising:
- mesosilicalite;
- and
- particles of a magnetic ferrite of formula MFe2O4 disposed in the pores of the mesosilicalite, where M is Cu;
- and
- a pharmaceutical agent mixture comprising cisplatin and curcumin disposed in the pores and/or on a surface of the nanocarrier;
- wherein the nanocarrier has a BET surface area of 70 m2/g and an average pore volume of 0.1 cm3/g,
- wherein the nanomedicinal composition releases 88% of the cisplatin and 40-50% of the curcumin over 72 hours in a solution with a pH of 5.6.
Dependencies are inferred from the claim text.