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US 12,097,259 B2Granted
Dendritic cell tumor vaccine and uses thereof
AssigneeShenzhen Frontiergate Biotechnology Co., Ltd
InventorYang Xu
Life of this patent
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Abstract
The present disclosure provides a dendric cell tumor vaccine comprising a chimeric antigen receptor for activating the dendritic cell and a tumor antigen. The present disclosure also provides compositions and methods of making the dendritic cell tumor vaccine, and the methods of using the dendritic cell tumor vaccine to treat cancer.
Claims21
A vector for preparing a dendritic cell (DC) tumor vaccine, comprising:
- (a) a polynucleotide encoding a chimeric antigen receptor (CAR) capable of activating a dendritic cell, wherein the CAR comprises (1) an extracellular antigen-binding domain comprising a single-chain variable fragment (scFv) specific for a tumor surface marker, (2) a transmembrane domain of CD8 alpha, and (3) an intracellular signaling domain comprising a cytoplasmic domain of Dectin-1 and a cytoplasmic domain of FcγR, wherein the intracellular signaling domain comprises the amino acid sequence set forth in SEQ ID NO:
- 3, and
- (b) a polynucleotide encoding a tumor antigen.
Dependencies are inferred from the claim text.