Pharmaceutical composition and kit for treating gout
AssigneeUniversity-Industry Foundation (Uif), Yonsei University
InventorJae-Chul Pyun
Life of this patent
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Abstract
The present invention relates to a pharmaceutical composition for treating gout and a gout treatment kit. According to an embodiment of the present invention, a pharmaceutical composition for treating gout comprising a probe containing at least one or more peptides specifically coupled to a monosodium urate (MSU) crystals and a first enzyme which is coupled to the probe and reacts with the target MSU crystal coupled to the probe or urea of surrounding joint fluid to remove the target MSU crystal is provided.
Claims17
A pharmaceutical composition for treating gout comprising,
- a probe containing at least one or more peptides specifically coupling to monosodium urate (MSU) crystals;
- and
- a first enzyme which reacts with a target MSU crystal coupled to the probe or urea of surrounding joint fluid to remove the target MSU crystal,
- wherein the at least one or more peptides are selected from the group consisting of SEQ ID NO:
- 1 to SEQ ID NO:
- 5, and
- wherein the first enzyme is selected from the group consisting of uricase, rasburicase, and urease.
A pharmaceutical composition for treating gout comprising, a support;
- a probe including at least one or more peptides which are coupled to and fixed to a portion of the support, and specifically coupled to monosodium urate, (MSU) crystals;
- and
- a first enzyme which is coupled to and fixed to other portion of the support, and reacts with a target MSU crystal coupled to the probe or urea of the surrounding joint fluid to remove the target MSU crystal,
- wherein the at least one or more peptides are selected from the group consisting of SEQ ID NO:
- 1 to SEQ ID NO:
- 5, and
- wherein the first enzyme is selected from the group consisting of uricase, rasburicase, and urease.
A gout treatment kit including a pharmaceutical composition comprising,
- a probe containing at least one or more peptides selectively reacting with monosodium urate MSU crystals;
- and
- a first enzyme which reacts with the target (MSU) crystal coupled to the probe, or urea of the surrounding joint fluid to remove the target MSU crystal,
- wherein the at least one or more peptides are selected from the group consisting of SEQ ID NO:
- 1 to SEQ ID NO:
- 5, and
- wherein the first enzyme is selected from the group consisting of uricase, rasburicase, and urease.
Dependencies are inferred from the claim text.