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US 12,092,640 B2Granted
Methods and compositions for diagnosis of rickettsia infection
OwnerAllan R. Brasier, Yingxin Zhao +2inventors
InventorsAllan R. Brasier, Yingxin Zhao, David H. Walker, Rong Fang
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Abstract
Certain embodiments are directed to detection methods and methods of identifying detection targets for sensitive and specific laboratory tests to diagnose and monitor rickettsial infections during the earliest stages of the disease and to assess the degree of illness.
Claims6
A method for detecting acute phase Rickettsial protein RC0497 in a sample comprising:
- contacting the sample with antibodies that bind Rickettsial protein RC0497 (SEQ ID NO:1) or Rickettsial protein RC0497 peptides forming an antibody complex with RC0497 peptides in the sample or RC0497 reactive antibodies in the sample, respectively;
- isolating the antibody complex;
- and
- identifying the peptides present in the antibody complex.
1 more element
Dependencies are inferred from the claim text.