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US 12,091,693 B2Granted
PSMA binding ligand-linker conjugates and methods for using
AssigneePurdue Research Foundation
InventorsPhilip Stewart Low, Venkatesh Chelvam, Youngsoon Kim, Sumith A Kularatne
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Abstract
Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
Claims17
A conjugate having the formula
- B-L-D
- or a salt thereof, wherein
- B is a ligand of PSMA comprising one or more of a carbon-sulfur double bond, a phosphorus-sulfur double bond, a phosphorus-sulfur single bond, a thioester, or a combination thereof;
- L is a divalent linker of 7 to 20 atoms in length, wherein the divalent linker comprises a divalent alkylene group, a cycloalkylenecarbonyl group and a hydrophobic side chain divalent group comprising an arylalkyl side chain;
- and
- D is drug comprising a radioactive isotope of a metal coordinated to a chelating group,
- the chelating group has the following formula
- wherein * is the point of attachment to the divalent linker;
- provided that the divalent linker has a single hydrophobic side chain divalent group in L.
6 more elements
Dependencies are inferred from the claim text.