Bispecific chimeric antigen receptors, encoding polynucleotides and use of receptors thereof to treat cancer
AssigneeSeattle Children's Hospital
InventorMichael Jensen
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Abstract
The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane domain; (d) at least one co-stimulatory domain; and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors.
Claims30
A bispecific chimeric antigen receptor (CAR), comprising:
- a. two antigen-specific targeting regions;
- b. a CD8a hinge extracellular spacer domain;
- c. a CD8a transmembrane domain;
- d. a 4-1BB co-stimulatory domain;
- and
- e. CD3 zeta intracellular signaling domain wherein each antigen-specific targeting region comprises an antigen-specific single-domain antibody, a variable domain, a VH domain, or a full length heavy chain.
Dependencies are inferred from the claim text.