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US 12,091,425 B2Granted
Compounds that inhibit MCL-1 protein
AssigneeAmgen Inc.
InventorsDavid Karl Bedke, Michael W. Gribble, Jr., Michael G. Johnson, Todd J. Kohn, Kexue Li
Life of this patent
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Abstract
Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.
Claims7
A compound, wherein the compound has a formula selected from one of the following:
- wherein TBS refers to the t-butyldimethylsilyl group.
Dependencies are inferred from the claim text.