Store overload-induced calcium release inhibitors and methods for producing and using the same

A compound of the formula:

• R1—X1-L-X2—R2
• wherein
• R1 is selected from the group consisting of:
• carbazol-2-yl;
• carbazol-3-yl;
• and carbazol-4-yl, each of which is optionally substituted;
• X1 is O;
• X2 is O;
• R2 is selected from the group consisting of substituted phenyl;
• substituted benzyl;
• optionally substituted benzo[d]oxazolyl, and optionally substituted benzofuranyl;
• and
• L is a linker selected from the group consisting of:
• wherein m is 1 or 2;
• and n is 1 to 4;
• provided
• when R1 is optionally substituted carbazol-4-yl, then R2 is optionally substituted benzyl;
• when R1 is unsubstituted carbazol-3-yl, then linker L has at least 7 backbone atoms in the chain;
• and
• when R1 is unsubstituted carbazol-2-yl, then linker L has at least 7 backbone atoms in the chain, and
• R2 is benzo[d]oxazolyl, benzofuranyl, or phenyl substituted with at least one substituent selected from halide and haloalkyl.