Back to results
US 12,091,390 B2Granted
Rosuvastatin calcium and process for producing intermediate thereof
AssigneeApi Corporation
InventorsNaoyuki Watanabe, Tomoko Maeda, Yasumasa Dekishima, Hiroshi Kawabata, Masaki Nagahama
Life of this patent
Estimating the term…
Abstract
An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.
Claims3
A production method of a compound represented by the following formula (1a):
- wherein R is a n-propyl group or an isopropyl group, comprising
- (iia) condensing a compound represented by the following formula (3):
- and a compound represented by the following formula (4a):
- wherein R2 is a tert-butyl group, in the presence of a base to obtain a compound represented by the following formula (5):
- wherein R2 is as defined for R2 in said formula (4a);
- and
- (iib) reacting the compound represented by formula (5) with an alcohol represented by R—OH wherein R is a n-propyl group or an isopropyl group.
4 more elements
Dependencies are inferred from the claim text.