Package and method for producing the same
AssigneeSeikagaku Corporation
InventorMine Higuchi
Life of this patent
Estimating the term…
Abstract
There is provided a package wherein a pharmaceutical composition containing a saccharide-degrading enzyme is contained in a container, whereby reduction in titer caused by a low amount of enzyme is suppressed. A package comprising a pharmaceutical composition and a container, wherein the pharmaceutical composition is a lyophilized preparation containing a saccharide-degrading enzyme as an active ingredient, and the container contains the pharmaceutical composition, the inner surface of the container comprising at least one material selected from the group consisting of fine ceramics, silicone resins and fluorine resins.
Claims15
A package comprising
- a pharmaceutical composition and a container,
- wherein the pharmaceutical composition is a lyophilized preparation containing a saccharide-degrading enzyme as an active ingredient,
- wherein the container contains the pharmaceutical composition and has at least one material selected from the group consisting of fine ceramics, silicone resins and fluorine resins at an inner surface of the container,
- wherein the saccharide-degrading enzyme is chondroitinase ABC, and
- wherein an amount of the enzyme in the container is less than 10 μg.
A method for producing a pharmaceutical composition contained in a container, the method comprising:
- putting a solution comprising a saccharide-degrading enzyme into the container having at least one material selected from the group consisting of fine ceramics, silicone resins and fluorine resins on its inner surface, and
- lyophilizing the solution,
- wherein the saccharide-degrading enzyme is chondroitinase ABC, and
- wherein an amount of the enzyme in the container is less than 10 μg.
A pharmaceutical composition obtained by lyophilizing a solution comprising a saccharide-degrading enzyme in a container which has at least one material selected from the group consisting of fine ceramics, silicone resins and fluorine resins at an inner surface of the container,
- wherein the saccharide-degrading enzyme is chondroitinase ABC, and
- wherein an amount of the enzyme in the container is less than 10 μg.
Dependencies are inferred from the claim text.