Suicide gene therapeutic agent for brain tumors using pluripotent stem cell
AssigneeKeio University
InventorsMasahiro Toda, Hideyuki Okano, Hiroyuki Miyoshi, Ryota Tamura
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Abstract
A cell preparation for treating brain tumors used in combination with a prodrug that is converted to 5-fluorouracil by cytosine deaminase, wherein the cell preparation comprises neural stem cells derived from pluripotent stem cells having a cytosine deaminase gene and a uracil phosphoribosyltransferase gene is provided to establish new means for treating brain tumors.
Claims10
A cell preparation for treating brain tumors used in combination with a prodrug that is converted to 5-fluorouracil by cytosine deaminase, wherein the cell preparation comprises neural stem cells derived from pluripotent stem cells having a cytosine deaminase gene and a uracil phosphoribosyltransferase gene.
Dependencies are inferred from the claim text.