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US 12,090,138 B2Granted
Pharmaceutical composition containing silybin and VE
AssigneeTasly Pharmaceutical Group Co., Ltd.
InventorsHe Sun, Xijun Yan, Naifeng Wu, Kaijing Yan, Yonghong Zhu, Shunnan Zhang, Xiaolin Bai, Xiaohui Ma, Yi He, Ting Li, Lei Li
Life of this patent
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Abstract
A pharmaceutical composition is prepared from the following raw materials (in parts by weight): silybin (8.75-60), phospholipid (15-65), a Pu'er tea extract (25-200), and vitamin E (6.25-40). The composition has the effect of treating non-alcoholic fatty liver diseases.
Claims8
A method of preparing a pharmaceutical preparation comprising:
- (1) preparing a silybin complex liquid by dissolving silybin and a phospholipid in anhydrous ethanol to provide a solution, heating and refluxing the solution, then concentrating the solution under reduced pressure to a concentrated volume, to thereby obtain the silybin complex liquid;
- (2) preparing granules by combining Pu'er tea extract as a base material with the silybin complex liquid prepared in step (1) in order to form a feed liquid, and producing the granules from the feed liquid by a fluidization spray method with a fluidized bed, and drying the granules;
- (3) mixing vitamin E with the granules uniformly in order to obtain a pharmaceutical composition;
- and
- (4) combining the pharmaceutical composition with one or more pharmaceutically acceptable carriers to produce the pharmaceutical preparation,
- wherein the pharmaceutical composition comprises 8.75-60 parts by weight of the silybin, 15-65 parts by weight of the phospholipid, 25-200 parts by weight of the Pu'er tea extract;
- and 6.25-40 parts by weight of the vitamin E.
4 more elements
Dependencies are inferred from the claim text.