Back to results
US 12,087,399 B2Granted
Systems and methods for customizing cell culture media for optimized cell proliferation based on genetic traits of cells
AssigneeSapphiros AI Bio LLC
InventorsRobin Y. Smith, Marcie A. Glicksman
Life of this patent
Estimating the term…
Abstract
Described herein are various systems and methods for customizing cell culture media for optimized cell proliferation based on genetic traits of the cells. Factors of the cells, such as genetics, can determine the optimum cell culture conditions for growth and use of individual cells in vitro. In certain embodiments, genetics can determine sensitivity from a toxic perspective. In certain embodiments, genetics can determine what concentration(s) of growth factor(s) and nutrient(s) are required for optimum growth.
Claims18
A method comprising:
- accessing, by a processor of a computing device, genotyping data corresponding to a population of cells, said genotyping data informative of one or more genetic traits of the population of cells, wherein the one or more genetic traits comprise at least one member selected from the group consisting of apoptosis, proliferation, genome instability, and acidosis,
- wherein the genotyping data comprises measurements of one or more single-nucleotide polymorphisms (SNPs), wherein the one or more SNPs affect a cellular function encoded by a cellular maintenance gene or a cell cycle gene;
- automatically identifying, by the processor, a composition for a cell culture medium based at least in part on the genotyping data, said composition selected for advantageous growth of the population of cells;
- and
- contacting the population of cells with the cell culture medium to grow the population of cells.
2 more elements
Dependencies are inferred from the claim text.