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US 12,085,576 B2Granted
Hybrid enzymatic aptamer sensors
AssigneeUniversity of Cincinnati
InventorJason Charles Heikenfeld
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Abstract
Devices and methods for sensing analytes in a solution sample are provided. The device includes a substrate, a conversion component configured to convert the analyte in the sample solution into a metabolite, and an aptamer sensor configured to measure a presence of the metabolite, the aptamer sensor located on the substrate.
Claims13
A device for sensing an analyte in a sample solution comprising:
- a substrate;
- a conversion component that converts analyte in the sample solution into a metabolite, the conversion component positioned on the substrate;
- an aptamer sensor that can detect or measure a presence of the metabolite, the aptamer sensor located on the substrate;
- wherein the conversion component is chosen from:
- (i) a source of enzymes, the enzymes being able to metabolize the analyte, and
- (ii) a metabolic pathway, the metabolic pathway being able to metabolize the analyte.
3 more elements
Dependencies are inferred from the claim text.