Modified antimicrobial peptide derived from an arginine-rich domain
AssigneeAcademia Sinica
InventorsChiaho Shih, Heng-Li Chen, Pei-Yi Su
Life of this patent
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Abstract
An antimicrobial peptide, the peptide comprising 2 to 20 variable domains, each variable domain is a sequence of 2 to 20 consecutive basic amino acids, wherein (a) the variable domains are separated from each other by a variable linker, (b) the variable linker can have 1 to 20 any amino acids other than two or more consecutive basic amino acids, and (c) the peptide has no more than 100 amino acids.
Claims21
An antimicrobial peptide, consisting of RRRGRSPRRRTPSPRRRRSQSPRRRRSC (SEQ ID NO:
- 7) or RRRGRPRRRPPRRRRQPRRRRC (SEQ ID NO:
- 9);
- optionally, at least one of the arginine residues in the peptide is D-arginine.
A chimeric antimicrobial peptide, consisting of RRRGRSPRRRTPSPRRRRSOSPRRRRSC (SEQ ID NO:
- 7) or RRRGRPRRRPPRRRRQPRRRRC (SEQ ID NO:
- 9), and an affinity tag, a signal sequence, a ligand, or another antimicrobial peptide or fragment thereof;
- optionally, at least one of the arginine residues in the peptide is D-arginine.
An antimicrobial peptide conjugate, the conjugate consisting of RRRGRSPRRRTPSPRRRRSQSPRRRRSC (SEQ ID NO:
- 7) or RRRGRPRRRPPRRRRQPRRRRC (SEQ ID NO:
- 9), and a non-peptide moiety;
- optionally, at least one of the arginine residues in the peptide is D-arginine.
Dependencies are inferred from the claim text.