Broad-spectrum carbapenems
AssigneeVenatorx Pharmaceuticals, Inc.
InventorsChristopher J. Burns, Guo-Hua Chu, Jodie Hamrick, Steven A. Boyd, Stephen M. Condon
Life of this patent
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Abstract
The present disclosure provides broad-spectrum carbapenem derivatives and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such derivatives and/or compositions.
Claims12
A compound of Formula (IVa-1), or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof:
- wherein:
- Ring A is cyclohexyl;
- R5 is hydrogen;
- each R6 is independently —NR60R61, —NR60(CR62R63)w6NR60R61, —NR60C(═NR61)NR60R61, —C(═NR60)NR60R61, —C(═NR60) R60, —N(R60)C(═NR61) R60, —(CR62R63) NR60R61, —C(═O)NR60R61—C(═O)(CR62R63)v6NR60R61, —(CR62R63)\N(R60)C(═NR61)NR60R61, or
- each R60 and R61 is independently selected from the group consisting of hydrogen and C1-C6 alkyl;
- each R62 and R63 is independently selected from the group consisting of hydrogen, halogen, and C1-C6 alkyl;
- v6 is 1 or 2:
- w6 is 2;
- n is 0 or 1;
- m is 0 or 1;
- p is 1;
- and
- q is 1 or 2.
A compound of Formula (IIa-1), or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof:
- wherein:
- Ring A is cyclohexyl;
- L is —(CR8R9)z —;
- each R8 and R9 are independently hydrogen or C1-C6 alkyl;
- R5 is hydrogen;
- each R6 is independently —NR60R61, —NR60(CR62R63) w6NR60R61, —NR60C(═NR61)NR60R61, —C(═NR60)NR60R61, —C(═NR60) R60, —N(R60)C(═NR61)R60, —(CR62R63)v6NR60R61, —C(═O)NR60R61, —C(═O)(CR62R63)v6NR60R61, —(CR62R63)v6N(R60)C(═NR61)NR60R61, or —(CR62R63)v6C(═NR61)NR6ºR61;
- each R60 and R61 is independently selected from the group consisting of hydrogen and C1-C6 alkyl;
- each R62 and R63 is independently selected from the group consisting of hydrogen, halogen, and C1-C6 alkyl;
- v6 is 1 or 2;
- w6 is 2;
- n is 1;
- m is 0 or 1;
- p is 1;
- q is 1 or 2;
- and
- z is 1 or 2.
A compound of Formula (IIIa-1), or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof:
- wherein:
- Ring A is cyclohexyl;
- L is —(CR8R9)z—;
- each R8 and R9 is independently hydrogen or C1-C6 alkyl;
- R5 is hydrogen;
- each R6 is independently —NR60R61, —NR60(CR62R63)w6NR60R61, —NR60C(═NR61)NR60R61, —C(═NR60)NR60R61, —C(═NR60) R60, —N(R60)C(═NR61) R60, —(CR62R63)v6NR60R61, —C(═O)NR60R61, —C(═O)(CR62R63)v6NR60R61, —(CR62R63)v6N(R60)C(═NR61)NR60R61, or —(CR62R63)v6C(═NR61)NR60R61;
- each R60 and R61 is independently selected from the group consisting of hydrogen and C1-C6 alkyl;
- each R62 and R63 is independently selected from the group consisting of hydrogen, halogen, and C1-C6 alkyl;
- v6 is 1 or 2:
- w6 is 2;
- n is 0 or 1;
- m is 0 or 1;
- p is 1;
- q is 1 or 2;
- and
- z is 1 or 2.
A compound selected from the group consisting of:
- or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof.
Dependencies are inferred from the claim text.