Substituted sulfonylurea derivatives

A compound having the structure of general formula (I)

• or a tautomeric form, a stereoisomer, an enantiomer, or a pharmaceutically acceptable salt, thereof,
• wherein,
• R1 at each occurrence is independently selected from hydrogen, halogen, haloalkyl, cyano, and optionally substituted groups selected from (C1-C6)alkyl, (C1-C6)haloalkyl, (C2-C6)alkenyl, (C1-C6)alkoxy, (C3-C7)cycloalkyl, NH2, NH(C1-C6)alkyl, N(C3-C7)cycloalkyl, N(C1-C6 alkyl)2, aryl, heteroaryl, heterocyclyl, benzyl, thiol, mercapto alkyl, SO2(C1-C6)alkyl, (C1-C6)thio-alkoxy, and amide;
• X is N—R5, O, S, or SO2;
• R5 at each occurrence is independently selected from hydrogen, halogen, haloalkyl, cyano, and optionally substituted groups selected from (C1-C6)alkyl, (C1-C6)haloalkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, (C3-C7)cycloalkyl, (C1-C6)alkylSO2(C1-C6)alkyl, (C1-C6)alkylN(C1-C6)alkyl, (C1-C6)alkylN(C3-C7)cycloalkyl, aryl, heteroaryl, heterocyclyl, benzyl, tert-butyloxycarbonyl, thiol, mercapto alkyl, SO2(C1-C6)alkyl, SO2(C3-C7)cycloalkyl, SO2-aryl, SO2-heterocyclyl, (C1-C6)thioalkyl, (C1-C6)thioalkoxy, (C1-C6)alkylSO2NH2, —CONH2, —CO(C1-C6)alkyl, —CO(C1-C6)haloalkyl, —CO-aryl, —CO-heteroaryl, —CO-heterocyclyl, 4- to 7-membered heterocyclic ring, 7- to 14-membered bicyclic heterocyclic ring system, and bridged or spiro ring system having optionally one or more than one heteroatoms;
• m and n is independently selected from integer 0-3;
• q and r is independently selected from integer 1-4;
• R2 at each occurrence is independently selected from hydrogen, halogen, cyano, and optionally substituted groups selected from (C1-C6)alkyl, (C2-C6)alkenyl, (C1-C6)alkoxy, (C3-C7)cycloalkyl, benzyl, aryl, heteroaryl, heterocyclyl, thiol, thioalkyl, thio-alkoxy, SO2(C1-C6)alkyl, SO(C1-C6)alkyl, and bridged or spiro ring system having optionally one or more than one heteroatoms;
• each of R3 and R4 at each occurrence is independently selected from hydrogen, halogen, haloalkyl, cyano, nitro, amide, sulphonamide, acyl, hydroxyl, and optionally substituted groups selected from (C1-C6)alkyl, (C1-C6)haloalkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, SO2(C1-C6)alkyl, thiol, mercapto alkyl, benzyl, aryl, heteroaryl, and heterocyclyl;
• alternatively R3 and R4 forms a bond;
• ‘B’ is selected from the following ring systems
• wherein X, Y, Z at each occurrence are independently selected from C, N, S, SO2 and O, which may, wherever possible be optionally substituted;
• each of R6, R7, R8, R9, R10 and R11 at each occurrence are independently selected from hydrogen, halogen, cyano, amide, sulphonamide, acyl, hydroxyl, and optionally substituted groups selected from (C1-C6)alkyl, (C1-C6)haloalkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, benzyl, aryl, heteroaryl, and heterocyclyl;
• alternatively each of R7 and R8, R8 and R9, R9 and R10 or R10 and R11 wherever possible, together may form a 4 to 7 membered saturated or partially saturated ring containing from 0-2 additional heteroatoms selected from the group consisting of N, O, and S(O)p;
• and
• p is 1 or 2.