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US 12,084,399 B2Granted
Crystalline tranilast salts and their pharmaceutical use
AssigneeNuformix Technologies Limited
InventorsJoanne Holland, Christopher Frampton
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AssigneeNuformix Technologies Limited
InventorsJoanne Holland, Christopher Frampton
Estimating the term…
The invention relates to crystalline tranilast salts. The crystalline tranilast salts, their preparation and their characterization are described and shown in the figures. The invention relates to pharmaceutical compositions containing a crystalline tranilast salt of the invention and a pharmaceutically acceptable carrier. The invention also relates to methods of treatment and the use of a therapeutically effective amount of a crystalline tranilast salt of the invention for treatment. The invention also relates to a method of preparing a liquid pharmaceutical composition comprising the step of dissolving a crystalline tranilast salt of the invention in a pharmaceutically acceptable solvent and to liquid pharmaceutical compositions prepared according to that method.
A method for the treatment of an allergic disorder, a fibrotic disorder or an inflammatory disorder comprising the step of administering to a patient in need thereof a pharmaceutical composition comprising a crystalline tranilast salt selected from the group consisting of crystalline 1:1 Tranilast N-methylglucamine form I, crystalline 1:1 Tranilast N-methylglucamine form II, crystalline 1:1 Tranilast L-Lysine, crystalline 1:1 Tranilast Diethylamine, crystalline 1:1 Tranilast N-ethylglucamine, crystalline 1:1 Tranilast Potassium Monohydrate, crystalline 1:1 Tranilast Diethanolamine, and crystalline 1:1 Tranilast Ethanolamine and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.