Inhibitors of SARM1 in combination with neuro-protective agents
AssigneeDisarm Therapeutics, Inc.
InventorsTodd Bosanac, Rajesh Devraj, Thomas Engber, Robert Owen Hughes, Raul Eduardo Krauss
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Abstract
The present disclosure relates to methods of treating neurodegeneration and neurodegenerative diseases comprising administering to a subject in need thereof a combination of a SARM1 inhibitor and a neuroprotective agent.
Claims9
A combination therapy comprising a SARM1 inhibitor selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof,
- and a DLK inhibitor of the structure
A method for treating and/or preventing axonal degeneration comprising administering to a patient in need thereof a SARM1 inhibitor selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof, in combination with a DLK inhibitor of the structure
A method comprising administering to a patient at risk for developing a neurodegenerative disease or disorder a SARM1 inhibitor selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof, in combination with a DLK inhibitor of the structure
Dependencies are inferred from the claim text.